Dr. Michael Leopold
Floyd D. and Elisabeth S. Gottwald Professor of Chemistry
Profile

Bioanalytical materials and biosensor development. Study of interactions between proteins and synthetic nanomaterials.

Publications
Articles

A.A. Galyean, H.S. Weinberg, R.D. Holbrook, and M.C. Leopold, “Characterization of Engineered Nanoparticles in Natural Waters,” In D. Barceló and M. Farré (Ed.), Comprehensive Analytical Chemistry Series #59, 2012, Elsevier Science, 169-195. [ISBN-13: 9780444563286]

J.T. Malinowski,* R.W. Day,* Rachel A. Courtney,* S.T. McCarron,* M.C. Leopold, and K.W. Kittredge, “A General Microwave-Assisted Synthesis of Substituted Crown Ethers with Pendant Alkyl or Aryl Ligands,” Open Journal of Organic Chemistry 2014, 2(1), 5-9.

M. Hillyer,* A. Cerel,* L. Finch,* J. Dattelbaum, and M.C. Leopold, “Multi-Technique Quantitative Analysis and Socioeconomic Considerations of Lead, Cadmium, and Arsenic in Children’s Toys and Toy Jewelry,” Chemosphere 2014, 108, 205-213.

A.R. Schmidt,* N.D.T. Nguyen,* and M.C. Leopold, “Nanoparticle Film Assemblies as Platforms for Electrochemical Biosensing – Factors Affecting Amperometric Signal Enhancement of Hydrogen Peroxide,” Langmuir 2013, 29(14), 4574-4583.

M.H. Freeman,* J.R. Hall,* and M.C. Leopold, “Monolayer-Protected Nanoparticle Doped Xerogels as Functional Components of Amperometric Glucose Biosensors,” Analytical Chemistry 2013, 85(8), 4057-4065.

T. T. Doan,* R.W. Day,* and M.C. Leopold (2012)  Optical and Electrochemical Properties of Multi-layer Polyelectrolyte Thin Films Incorporating Spherical, Gold Colloid Nanomaterials.  J. Materials Science, 47, 108-120.  

D. Campbell-Rance, T. Doan,* and M.C. Leopold (2011)  Sweep, Step, Pulse, and Frequency-Based Techniques Applied to Protein Monolayer Electrochemistry at Nanoparticle Interfaces. J. Electroanalytical Chemistry, 662(2), 343-354.

T.T. Doan,* M. Freeman,* A. Schmidt,* N. Nguyen,* and M.C. Leopold (2011)  Synthesis, Assembly, and Characterization of Monolayer-Protected Gold Nanoparticle Films for Protein Monolayer Electrochemistry.  J. of Visualized Experiments, 56, e3441, [DOI: 10.3791/3441], [URL: http://www.jove.com/details.php?id=3441]

H. Weinberg, A. Galyean, and M. Leopold (2011)  Evaluating Engineered Nanoparticles in Natural Waters. Trends in Analytical Chemistry, 30(1), 72-83.

C.E. Dowdy* and M.C. Leopold (2010)  Enhanced Electrochemistry of Nanoparticle-Embedded Polyelectrolyte Films: Interfacial Electronic Coupling and Distance Dependence. Thin Solid Films, 519, 790-796.

T. Doan,* M.L. Vargo,* J.K. Gerig,* C.P. Gulka,* M.L. Trawick, J.D. Dattelbaum and M.C. Leopold (2010)  Electrochemical Investigation of Azurin Thermodynamic and Adsorption Properties at Monolayer-Protected Cluster Film Assemblies-Evidence for a More Homogeneous Adsorption Interface.  J. of Colloid and Interface Science, 352, 50-58.

C.E. Dowdy* and M.C. Leopold (2010)  Enhanced Electrochemistry of Nanoparticle-Embedded Polyelectrolyte Films: Interfacial Electronic Coupling and Distance Dependence. Thin Solid Films, 519, 790-796.v

T. Doan,* M.L. Vargo,* J.K. Gerig,* C.P. Gulka,* M.L. Trawick, J.D. Dattelbaum and M.C. Leopold (2010)  Electrochemical Investigation of Azurin Thermodynamic and Adsorption Properties at Monolayer-Protected Cluster Film Assemblies-Evidence for a More Homogeneous Adsorption Interface.  J. of Colloid and Interface Science, 352, 50-58.

M.L. Vargo,* C.P. Gulka,* J.K. Gerig,* C.M. Manieri,* J.D. Dattelbaum, C.B. Marks, N.T. Lawrence,* M.L. Trawick, and M.C. Leopold (2010)  Distance Dependence of Electron Transfer Kinetics for Azurin Protein Adsorbed to Monolayer Protected Nanoparticle Film Assemblies.  Langmuir, 26(1), 560-569.

A.A. Galyean,* R.W. Day,* J. Malinowski,* K.W. Kittredge, and M.C. Leopold (2009)  Polyelectrolyte- Linked Film Assemblies of Nanoparticles and Nanoshells : Growth, Stability, and Optical Properties.  J. of Colloid and Interface Science, 331, 532-542.

A.F. Loftus,* K.P. Reighard,* S.A. Kapourales,* and M.C. Leopold (2008)  Monolayer-Protected Nanoparticle Film Assemblies as Platforms for Controlling Interfacial and Adsorption Properties in Protein Monolayer Electrochemistry.  J. Am. Chem. Soc., 130, 1649-1661. 

L.E. Russell, R.R. Pompano, K.W. Kittredge and M.C. Leopold (2007) Assembled Nanoparticle Films with Crown Ether-Metal Ion 'Sandwiches' as Sensing Mechanisms for Metal Ions. Journal of Materials Science, v. 42, no. 17, 7100-7108.

L.E. Russell,* A.A. Galyean,* S.M. Notte,* and M.C. Leopold (2007)  Stable Aqueous Nanoparticle Film Assemblies with Covalent and Charged Polymer Linking Networks.  Langmuir, 23(14), 7446-7471.

K.W. Kittredge, L.E. Russell,* and M.C. Leopold (2007)  A Series of Vertically Integrated Nanotechnology Experiments for the Undergraduate Curriculum. Chemical Educator, 12(3), 155-158.

R.R. Pompano,* P.G. Wortley,* L.M. Moatz,* DJ Tognarelli,* K.W. Kittredge, M.C. Leopold (2006)  Crown Ether-Metal ‘Sandwiches’ As Linking Mechanisms in Assembled Nanoparticle Films” Thin Solid Films, 510, 311-319.

DJ Tognarelli,* R.B. Miller, R.R. Pompano,* A.F. Loftus,* D.J. Sheibley,* and M.C. Leopold (2005) Covalently Networked Monolayer Protected Nanoparticle Films.  Langmuir, 21(24), 11119-11127. 

D. Sheibley*, D.J. Tognarelli*, R. Szymanik* and M.C. Leopold (2005) Ultra-fast Formation and Characterization of Stable Nanoparticle Film Assemblies. Journal of Materials Chemistry, 15, 491-498.

M.C. Leopold, R.L. Donkers, D. Georganopoulou, M. Fisher*, F.P. Zamborini, and R.W. Murray (2004) Growth, Conductivity, and Vapor Response Properties of Metal Ion-Carboxylate Linked Nanoparticle Films. Faraday Discuss., 125, 63-76.

V.L. Jimenz, M.C. Leopold, C. Mazzitelli*, J.W. Jorgenson and R.W. Murray (2003) Reversed-Phase HPLC Separation of Monolayer Protected Gold Nanoclusters. Anal. Chem., 75(2), 199-206.

D.T. Miles, M.C. Leopold and R.W. Murray (2003) Simulations of Quantized Double Layer Charging Voltammetry of Poly-Disperse and Mono-Disperse Monolayer Protected Clusters.  J. Electroanal. Chem., 554-555, 87-97.

F.P. Zamborini, L.A. Smart*, M.C. Leopold, and R.W. Murray (2003) Distance-Dependent Electron Hopping Conductivity and Nanoscale Lithography of Chemically-Linked Gold Monolayer-Protected Cluster Films. Analytica Chimica Acta, 496, 3-16.

R.L. Donkers, M.C. Leopold and R.W. Murray (2002) Growth and Conductivity of Monolayer-Protected Cluster Films - New Strategies. Proceedings of the 201st Meeting of the Electrochemical Society, Organic and Biological Electrochemistry Society.

F.P. Zamborini, M.C. Leopold, J.F. Hicks, P.J. Kulesza, M.A. Malik and R.W. Murray (2002) Electron Hopping Conductivity and Vapor Sensing Properties of Flexible Network Films of Metal Nanoparticles. Journal of the American Chemical Society, 124(30), 8958-8964.

M.C. Leopold, J.A. Black* and E.F. Bowden (2002) Influence of Gold Topography on Carboxylic Acid Terminated Self-Assembled Monolayers. Langmuir, 18, 978-980.

M.C. Leopold and E.F. Bowden (2002) The Influence of Gold Substrate Topography on the Voltammetry of Cytochrome c Adsorbed on Carboxylic Acid Terminated Self- Assembled Monolayers. Langmuir, 18(6), 2239-2245.

A. El Kasmi, M.C. Leopold, R. Galligan*, R.T. Robertson, S.S. Saavedra, K. El Kacemi and E.F. Bowden (2002) Adsorption Immobilization of Cytochrome c on Indium/Tin Oxide (ITO): Electrochemical Evidence for Electron Transfer Induced Conformational Changes. Electrochemistry Communications, 4, 177-181.


Education
Ph.D., North Carolina State University
Contact Information
(804) 287-6329
(804) 287-1897 (Fax)
Areas of Expertise
Bioanalytical Nanomaterials